Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 796990..797598 Replicon chromosome
Accession NZ_CP104913
Organism Pseudomonas aeruginosa strain PA-AUTBAM

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag N2X48_RS03755 Protein ID WP_003114156.1
Coordinates 797251..797598 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag N2X48_RS03750 Protein ID WP_003114155.1
Coordinates 796990..797241 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2X48_RS03730 (N2X48_03730) 792637..792993 + 357 WP_003114150.1 DUF2523 family protein -
N2X48_RS03735 (N2X48_03735) 792997..794271 + 1275 WP_010895520.1 zonular occludens toxin family protein -
N2X48_RS03740 (N2X48_03740) 794501..795793 + 1293 WP_003115206.1 hypothetical protein -
N2X48_RS03745 (N2X48_03745) 795793..796776 + 984 WP_003114154.1 tyrosine-type recombinase/integrase -
N2X48_RS03750 (N2X48_03750) 796990..797241 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N2X48_RS03755 (N2X48_03755) 797251..797598 + 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N2X48_RS03765 (N2X48_03765) 797925..798827 - 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
N2X48_RS03770 (N2X48_03770) 799279..800016 - 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
N2X48_RS03775 (N2X48_03775) 800096..801139 - 1044 WP_003098363.1 L,D-transpeptidase -
N2X48_RS03780 (N2X48_03780) 801275..801967 - 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
N2X48_RS03785 (N2X48_03785) 801967..802239 - 273 WP_010895521.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 783009..797598 14589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T259472 WP_003114156.1 NZ_CP104913:797251-797598 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT259472 WP_003114155.1 NZ_CP104913:796990-797241 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References