Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1885947..1886513 Replicon chromosome
Accession NZ_CP104882
Organism Aggregatibacter actinomycetemcomitans strain IDHaas10a

Toxin (Protein)


Gene name higB Uniprot ID X2JU35
Locus tag N7761_RS09375 Protein ID WP_005543444.1
Coordinates 1886235..1886513 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag N7761_RS09370 Protein ID WP_005543446.1
Coordinates 1885947..1886219 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7761_RS09345 (N7761_09345) 1882487..1882753 - 267 WP_005543457.1 oxaloacetate decarboxylase subunit gamma -
N7761_RS09350 (N7761_09350) 1883114..1883305 + 192 WP_005553960.1 hypothetical protein -
N7761_RS09355 (N7761_09355) 1883280..1883657 + 378 WP_005543455.1 hypothetical protein -
N7761_RS09360 (N7761_09360) 1883778..1884053 - 276 WP_005561117.1 hydrogenase maturation factor HybG -
N7761_RS09365 (N7761_09365) 1884508..1885938 - 1431 WP_005566276.1 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF -
N7761_RS09370 (N7761_09370) 1885947..1886219 - 273 WP_005543446.1 HigA family addiction module antitoxin Antitoxin
N7761_RS09375 (N7761_09375) 1886235..1886513 - 279 WP_005543444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7761_RS09380 (N7761_09380) 1886608..1887609 - 1002 WP_014167798.1 anthranilate phosphoribosyltransferase -
N7761_RS09385 (N7761_09385) 1887621..1888013 - 393 WP_005543439.1 tautomerase family protein -
N7761_RS09390 (N7761_09390) 1888087..1888677 - 591 WP_005572120.1 aminodeoxychorismate/anthranilate synthase component II -
N7761_RS09395 (N7761_09395) 1888688..1890235 - 1548 WP_005572118.1 anthranilate synthase component 1 -
N7761_RS09400 (N7761_09400) 1890403..1890957 - 555 WP_005543432.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-79)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10490.95 Da        Isoelectric Point: 9.5983

>T259458 WP_005543444.1 NZ_CP104882:c1886513-1886235 [Aggregatibacter actinomycetemcomitans]
MILSFKHKGLEQFFKTGSTAGIQAKHAKKLNLQLATLNNAETPLAMSVPSWNLHKLKGDLQEHWAVTVNGNWRLTFKFEN
GHAEVVDYQDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10138.74 Da        Isoelectric Point: 7.3169

>AT259458 WP_005543446.1 NZ_CP104882:c1886219-1885947 [Aggregatibacter actinomycetemcomitans]
MHNPPHPGELLKEYIDGVSVTKVAQKLGVSRVTLSRILNGKASITPEMAVRLSELLNTTTPKLWLGMQADYDLWQIEQQH
AVFNIQPLFN

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X2JU35

Antitoxin

Source ID Structure

References