Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 11228..11874 Replicon chromosome
Accession NZ_CP104882
Organism Aggregatibacter actinomycetemcomitans strain IDHaas10a

Toxin (Protein)


Gene name higB Uniprot ID X2JQ23
Locus tag N7761_RS00060 Protein ID WP_005555126.1
Coordinates 11524..11874 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID X2JT85
Locus tag N7761_RS00055 Protein ID WP_005540827.1
Coordinates 11228..11527 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7761_RS00045 (N7761_00045) 7830..8057 - 228 WP_005567423.1 hypothetical protein -
N7761_RS00050 (N7761_00050) 8259..11192 + 2934 WP_014167733.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -
N7761_RS00055 (N7761_00055) 11228..11527 - 300 WP_005540827.1 helix-turn-helix transcriptional regulator Antitoxin
N7761_RS00060 (N7761_00060) 11524..11874 - 351 WP_005555126.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7761_RS00065 (N7761_00065) 12062..13645 - 1584 WP_005567417.1 peptide chain release factor 3 -
N7761_RS00070 (N7761_00070) 14002..14829 + 828 WP_005540818.1 hypothetical protein -
N7761_RS00075 (N7761_00075) 14924..16261 + 1338 WP_005567415.1 argininosuccinate synthase -
N7761_RS00080 (N7761_00080) 16451..16696 + 246 WP_005540815.1 YgjV family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13518.64 Da        Isoelectric Point: 9.9664

>T259452 WP_005555126.1 NZ_CP104882:c11874-11524 [Aggregatibacter actinomycetemcomitans]
MWAVILTERFETWLNQQPIKTQECVLANLVRLEHFGPNLARPYVDSVAGSIHSNMKELRVQHSGRAIRLFFAFDPKRRAI
VLCGGDKGNDKRFYRTMIRIADQELNHYLATMEQTK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11342.12 Da        Isoelectric Point: 5.8598

>AT259452 WP_005540827.1 NZ_CP104882:c11527-11228 [Aggregatibacter actinomycetemcomitans]
MKTLQQVIDERSVESRQRIQTMAEDLILETGLQLLREELNISQQQLATILGVTQPAINQLEQRGNEIKLATLKRYIEAMG
GKLRLSVEMPDGHQRVFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X2JQ23

Antitoxin

Source ID Structure
AlphaFold DB X2JT85

References