259435

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6041631..6042226 Replicon chromosome
Accession NZ_CP104870
Organism Pseudomonas aeruginosa strain PALA9

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA9_RS28145 Protein ID WP_003117425.1
Coordinates 6041948..6042226 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA9_RS28140 Protein ID WP_003099268.1
Coordinates 6041631..6041936 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA9_RS28110 (PALA9_05567) 6037084..6037374 - 291 WP_023083237.1 DUF5447 family protein -
PALA9_RS28115 (PALA9_05568) 6037586..6037858 - 273 WP_003115921.1 hypothetical protein -
PALA9_RS28120 (PALA9_05569) 6037968..6038234 + 267 WP_016852153.1 hypothetical protein -
PALA9_RS28125 (PALA9_05570) 6038366..6039202 + 837 WP_223656480.1 helix-turn-helix domain-containing protein -
PALA9_RS28130 (PALA9_05571) 6039177..6040715 + 1539 WP_023082696.1 GNAT family N-acetyltransferase -
PALA9_RS28135 6040727..6041254 - 528 WP_071535723.1 ATP-binding protein -
PALA9_RS28140 (PALA9_05572) 6041631..6041936 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA9_RS28145 6041948..6042226 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA9_RS28150 6042279..6042407 - 129 Protein_5566 integrase -
PALA9_RS28155 (PALA9_05573) 6042555..6044783 + 2229 WP_003099265.1 TonB-dependent receptor -
PALA9_RS28160 (PALA9_05574) 6044853..6045500 - 648 WP_003095021.1 carbonate dehydratase -
PALA9_RS28165 (PALA9_05575) 6045562..6046800 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T259435 WP_003117425.1 NZ_CP104870:c6042226-6041948 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT259435 WP_003099268.1 NZ_CP104870:c6041936-6041631 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References