259427

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5643303..5643898 Replicon chromosome
Accession NZ_CP104869
Organism Pseudomonas aeruginosa strain PALA8

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA8_RS26225 Protein ID WP_003113526.1
Coordinates 5643620..5643898 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA8_RS26220 Protein ID WP_003133769.1
Coordinates 5643303..5643608 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA8_RS26185 5638325..5638615 - 291 WP_031757220.1 DUF5447 family protein -
PALA8_RS26190 (PALA8_05216) 5638791..5639063 - 273 WP_004352675.1 hypothetical protein -
PALA8_RS26195 5639175..5639447 + 273 WP_071543058.1 DNA-binding protein -
PALA8_RS26200 (PALA8_05217) 5639503..5639838 + 336 WP_023094905.1 hypothetical protein -
PALA8_RS26205 5639932..5640522 + 591 WP_071536478.1 SLATT domain-containing protein -
PALA8_RS26210 (PALA8_05218) 5640519..5641784 + 1266 WP_023094906.1 nucleotidyltransferase -
PALA8_RS26215 (PALA8_05219) 5641868..5642860 - 993 WP_003133766.1 hypothetical protein -
PALA8_RS26220 (PALA8_05220) 5643303..5643608 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
PALA8_RS26225 5643620..5643898 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA8_RS26230 5643951..5644079 - 129 Protein_5184 integrase -
PALA8_RS26235 (PALA8_05221) 5644227..5646455 + 2229 WP_003133778.1 TonB-dependent receptor -
PALA8_RS26240 (PALA8_05222) 5646526..5647173 - 648 WP_003095021.1 carbonate dehydratase -
PALA8_RS26245 (PALA8_05223) 5647235..5648473 - 1239 WP_003095023.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T259427 WP_003113526.1 NZ_CP104869:c5643898-5643620 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT259427 WP_003133769.1 NZ_CP104869:c5643608-5643303 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References