Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5009878..5010559 Replicon chromosome
Accession NZ_CP104869
Organism Pseudomonas aeruginosa strain PALA8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA8_RS23255 Protein ID WP_015503432.1
Coordinates 5010194..5010559 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA8_RS23250 Protein ID WP_004364117.1
Coordinates 5009878..5010201 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA8_RS23220 (PALA8_04625) 5005654..5006231 + 578 Protein_4596 plasmid pRiA4b ORF-3 family protein -
PALA8_RS23225 5006597..5006992 - 396 Protein_4597 hypothetical protein -
PALA8_RS23235 (PALA8_04629) 5008252..5009256 - 1005 Protein_4599 tyrosine-type recombinase/integrase -
PALA8_RS23240 (PALA8_04631) 5009256..5009648 - 393 Protein_4600 hypothetical protein -
PALA8_RS23245 5009643..5009762 + 120 Protein_4601 IS5/IS1182 family transposase -
PALA8_RS23250 (PALA8_04632) 5009878..5010201 - 324 WP_004364117.1 XRE family transcriptional regulator Antitoxin
PALA8_RS23255 5010194..5010559 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA8_RS23260 5010823..5011062 - 240 WP_044069615.1 hypothetical protein -
PALA8_RS23265 (PALA8_04633) 5011269..5011541 + 273 WP_004364121.1 hypothetical protein -
PALA8_RS23270 (PALA8_04634) 5011572..5011997 - 426 WP_003116492.1 VOC family protein -
PALA8_RS23275 (PALA8_04635) 5012098..5012982 + 885 WP_004364122.1 LysR substrate-binding domain-containing protein -
PALA8_RS23280 (PALA8_04636) 5012955..5013908 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
PALA8_RS23285 (PALA8_04637) 5014129..5014563 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4976435..5011997 35562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T259425 WP_015503432.1 NZ_CP104869:c5010559-5010194 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT259425 WP_004364117.1 NZ_CP104869:c5010201-5009878 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GHLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References