Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5546667..5547262 Replicon chromosome
Accession NZ_CP104868
Organism Pseudomonas aeruginosa strain PALA7

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA7_RS25790 Protein ID WP_003113526.1
Coordinates 5546984..5547262 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA7_RS25785 Protein ID WP_003099268.1
Coordinates 5546667..5546972 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA7_RS25750 (PALA7_05094) 5541806..5542654 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA7_RS25760 (PALA7_05096) 5542821..5543762 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA7_RS25765 (PALA7_05097) 5543879..5544493 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA7_RS25770 (PALA7_05098) 5544535..5545119 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA7_RS25775 (PALA7_05099) 5545160..5546260 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA7_RS25785 (PALA7_05101) 5546667..5546972 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA7_RS25790 5546984..5547262 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA7_RS25795 5547315..5547443 - 129 Protein_5097 integrase -
PALA7_RS25800 (PALA7_05102) 5547591..5549819 + 2229 WP_003099265.1 TonB-dependent receptor -
PALA7_RS25805 (PALA7_05103) 5549889..5550536 - 648 WP_003095021.1 carbonate dehydratase -
PALA7_RS25810 (PALA7_05104) 5550598..5551836 - 1239 WP_003099263.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T259418 WP_003113526.1 NZ_CP104868:c5547262-5546984 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT259418 WP_003099268.1 NZ_CP104868:c5546972-5546667 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References