Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5806737..5807278 Replicon chromosome
Accession NZ_CP104866
Organism Pseudomonas aeruginosa strain PALA4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA4_RS27050 Protein ID WP_003111576.1
Coordinates 5807009..5807278 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA4_RS27045 Protein ID WP_269973773.1
Coordinates 5806737..5806997 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA4_RS27020 (PALA4_05339) 5801878..5802150 - 273 WP_003115921.1 hypothetical protein -
PALA4_RS27025 5802738..5802932 + 195 WP_003111573.1 hypothetical protein -
PALA4_RS27030 (PALA4_05340) 5803052..5804485 - 1434 WP_020750803.1 hypothetical protein -
PALA4_RS27035 5804748..5805131 - 384 WP_003111574.1 hypothetical protein -
PALA4_RS27045 (PALA4_05342) 5806737..5806997 - 261 WP_269973773.1 HigA family addiction module antitoxin Antitoxin
PALA4_RS27050 5807009..5807278 - 270 WP_003111576.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA4_RS27055 5807331..5807459 - 129 Protein_5347 integrase -
PALA4_RS27060 (PALA4_05343) 5807607..5809835 + 2229 WP_023443586.1 TonB-dependent receptor -
PALA4_RS27065 (PALA4_05344) 5809906..5810553 - 648 WP_003095021.1 carbonate dehydratase -
PALA4_RS27070 (PALA4_05345) 5810615..5811853 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5806398..5806676 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-89)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10330.76 Da        Isoelectric Point: 7.8937

>T259406 WP_003111576.1 NZ_CP104866:c5807278-5807009 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTDAGP
EEVEIVDYH

Download         Length: 270 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9560.92 Da        Isoelectric Point: 4.9681

>AT259406 WP_269973773.1 NZ_CP104866:c5806997-5806737 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAAN

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References