Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5181153..5181748 Replicon chromosome
Accession NZ_CP104865
Organism Pseudomonas aeruginosa strain PALA2

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA2_RS24195 Protein ID WP_003117425.1
Coordinates 5181470..5181748 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA2_RS24190 Protein ID WP_003113527.1
Coordinates 5181153..5181458 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA2_RS24155 (PALA2_04801) 5176293..5177141 + 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA2_RS24165 (PALA2_04803) 5177308..5178249 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA2_RS24170 (PALA2_04804) 5178366..5178980 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA2_RS24175 (PALA2_04805) 5179022..5179606 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA2_RS24180 (PALA2_04806) 5179647..5180747 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA2_RS24190 (PALA2_04808) 5181153..5181458 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA2_RS24195 5181470..5181748 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA2_RS24200 5181801..5181929 - 129 Protein_4777 integrase -
PALA2_RS24205 (PALA2_04809) 5182077..5184305 + 2229 WP_003113525.1 TonB-dependent receptor -
PALA2_RS24210 (PALA2_04810) 5184375..5185022 - 648 WP_003095021.1 carbonate dehydratase -
PALA2_RS24215 (PALA2_04811) 5185084..5186322 - 1239 WP_003117424.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T259395 WP_003117425.1 NZ_CP104865:c5181748-5181470 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT259395 WP_003113527.1 NZ_CP104865:c5181458-5181153 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References