259385

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4917418..4918112 Replicon chromosome
Accession NZ_CP104861
Organism Pseudomonas fragi strain D12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N7D90_RS22520 Protein ID WP_261740041.1
Coordinates 4917825..4918112 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7D90_RS22515 Protein ID WP_261740040.1
Coordinates 4917418..4917819 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7D90_RS22505 (N7D90_22505) 4915208..4916671 + 1464 WP_261740038.1 YdiU family protein -
N7D90_RS22510 (N7D90_22510) 4917150..4917425 + 276 WP_261740039.1 DUF3077 domain-containing protein -
N7D90_RS22515 (N7D90_22515) 4917418..4917819 - 402 WP_261740040.1 transcriptional regulator Antitoxin
N7D90_RS22520 (N7D90_22520) 4917825..4918112 - 288 WP_261740041.1 type II toxin-antitoxin system HigB family toxin Toxin
N7D90_RS22525 (N7D90_22525) 4918419..4920215 + 1797 WP_261740042.1 SLC13 family permease -
N7D90_RS22530 (N7D90_22530) 4920368..4920808 + 441 WP_261740043.1 thioredoxin TrxC -
N7D90_RS22535 (N7D90_22535) 4920805..4921578 - 774 WP_261740044.1 ParA family protein -
N7D90_RS22540 (N7D90_22540) 4921826..4922608 + 783 WP_261740045.1 beta-ketoacyl synthase chain length factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-130)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11420.18 Da        Isoelectric Point: 10.5593

>T259385 WP_261740041.1 NZ_CP104861:c4918112-4917825 [Pseudomonas fragi]
MRVITAKRIWEAKEQWPQSANALDEWYRKIKVLNPEDFAALRSFFPATDKVGSFHVFNMGGNKLRLIALVRYRVQRLYIR
HVLDHRDYDKGNWKE

Download         Length: 288 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14955.05 Da        Isoelectric Point: 4.3897

>AT259385 WP_261740040.1 NZ_CP104861:c4917819-4917418 [Pseudomonas fragi]
MNALVEQAVEHWQFVSPLLRKPKNEADYDALVAALDQLSDLIGDDESHPLMSLVDIIGDWVEAYDLEHRPMPKASGVDVL
RSVMQEHGLTQSDLPGVGTQSVVSEILSGKRQLNVRQIRWLADYFKVPVDMFI

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References