Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1934055..1934657 Replicon chromosome
Accession NZ_CP104858
Organism Salmonella sp. 3C

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag N7E69_RS09220 Protein ID WP_001159635.1
Coordinates 1934055..1934366 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7E69_RS09225 Protein ID WP_000362050.1
Coordinates 1934367..1934657 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E69_RS09185 (1929168) 1929168..1929767 + 600 WP_000965695.1 glucose-1-phosphatase -
N7E69_RS09190 (1929761) 1929761..1930633 + 873 WP_000921423.1 virulence factor BrkB family protein -
N7E69_RS09195 (1930630) 1930630..1931067 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
N7E69_RS09200 (1931112) 1931112..1932053 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
N7E69_RS09205 (1932068) 1932068..1932514 - 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
N7E69_RS09210 (1932511) 1932511..1932822 - 312 WP_000558169.1 type II toxin-antitoxin system HigB family toxin -
N7E69_RS09215 (1932908) 1932908..1933837 - 930 WP_001127708.1 alpha/beta hydrolase -
N7E69_RS09220 (1934055) 1934055..1934366 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
N7E69_RS09225 (1934367) 1934367..1934657 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
N7E69_RS09230 (1934704) 1934704..1935633 - 930 WP_000027737.1 formate dehydrogenase accessory protein FdhE -
N7E69_RS09235 (1935630) 1935630..1936265 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
N7E69_RS09240 (1936262) 1936262..1937164 - 903 WP_000331367.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T259368 WP_001159635.1 NZ_CP104858:1934055-1934366 [Salmonella sp. 3C]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT259368 WP_000362050.1 NZ_CP104858:1934367-1934657 [Salmonella sp. 3C]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References