Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1384818..1385356 Replicon chromosome
Accession NZ_CP104858
Organism Salmonella sp. 3C

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag N7E69_RS06660 Protein ID WP_001526148.1
Coordinates 1384818..1385093 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag N7E69_RS06665 Protein ID WP_000729713.1
Coordinates 1385096..1385356 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E69_RS06655 (1382025) 1382025..1384730 + 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -
N7E69_RS06660 (1384818) 1384818..1385093 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
N7E69_RS06665 (1385096) 1385096..1385356 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N7E69_RS06670 (1385465) 1385465..1386476 - 1012 Protein_1300 RNA 3'-terminal phosphate cyclase -
N7E69_RS06675 (1386480) 1386480..1387694 - 1215 WP_001105533.1 RNA-splicing ligase RtcB -
N7E69_RS06680 (1388042) 1388042..1389595 - 1554 WP_000013013.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T259364 WP_001526148.1 NZ_CP104858:c1385093-1384818 [Salmonella sp. 3C]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT259364 WP_000729713.1 NZ_CP104858:c1385356-1385096 [Salmonella sp. 3C]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References