25936

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 812760..814108 Replicon chromosome
Accession NC_016809
Organism Haemophilus influenzae 10810

Toxin (Protein)


Gene name HipT Uniprot ID A0A2X4XRN4
Locus tag HIB_RS04235 Protein ID WP_005690165.1
Coordinates 812760..813791 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F9GV76
Locus tag HIB_RS04240 Protein ID WP_005635266.1
Coordinates 813788..814108 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIB_RS04225 809280..811025 + 1746 WP_015701795.1 ABC transporter ATP-binding protein/permease -
HIB_RS04230 811018..812676 + 1659 WP_015701796.1 thiol reductant ABC exporter subunit CydC -
HIB_RS04235 812760..813791 - 1032 WP_005690165.1 type II toxin-antitoxin system HipA family toxin Toxin
HIB_RS04240 813788..814108 - 321 WP_005635266.1 type II toxin-antitoxin system HipA family toxin Antitoxin
HIB_RS04245 814096..814404 - 309 WP_005690167.1 helix-turn-helix domain-containing protein -
HIB_RS04250 814604..815605 - 1002 WP_005690169.1 class II fructose-bisphosphatase -
HIB_RS04255 815767..815985 + 219 WP_005650820.1 cell division protein ZapB -
HIB_RS04260 816083..816523 + 441 WP_005667635.1 FMN-binding protein MioC -
HIB_RS04265 816520..816954 + 435 WP_005690172.1 D-tyrosyl-tRNA(Tyr) deacylase -
HIB_RS04270 817259..817735 - 477 WP_005661209.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
HIB_RS04275 817732..818409 - 678 WP_005690174.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
HIB_RS04280 818409..818687 - 279 WP_005661211.1 cell division protein FtsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39855.45 Da        Isoelectric Point: 6.5777

>T25936 WP_005690165.1 NC_016809:c813791-812760 [Haemophilus influenzae 10810]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKTMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLAFLNLLNEPEL

Download         Length: 1032 bp

>T25936 NC_016809:c813791-812760 [Haemophilus influenzae 10810]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCTTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGATCACTTTAACAGCATAAATCAACAG
GGAAACTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATAAACAGCAAAAAACAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCAGATAATGAGCAATATGTAAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACAGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGTGCGAGAAGAGGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTTCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12441.11 Da        Isoelectric Point: 5.9670

>AT25936 WP_005635266.1 NC_016809:c814108-813788 [Haemophilus influenzae 10810]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT25936 NC_016809:c814108-813788 [Haemophilus influenzae 10810]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4XRN4

Antitoxin

Source ID Structure
AlphaFold DB F9GV76

References