Detailed information of TA system TA259355

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2948981..2949318
• Replicon: chromosome
• Accession: NZ_CP104856
• Organism: Enterococcus faecalis strain NY13412

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: N7M47_RS14330
• Protein ID: WP_002396786.1
• Coordinates: 2948981..2949124 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2949056..2949318 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N7M47_RS14310	2944197..2944412	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
N7M47_RS14315	2944551..2945543	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
N7M47_RS14320	2945710..2946348	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
N7M47_RS14325	2947033..2948649	+	1617	WP_002378864.1	phosphatase PAP2/LCP family protein	-
N7M47_RS14330	2948981..2949124	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	2949056..2949318	-	263	-	-	Antitoxin
N7M47_RS14335	2949319..2954010	-	4692	WP_002378865.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T259355 WP_002396786.1 NZ_CP104856:2948981-2949124 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT259355 NZ_CP104856:c2949318-2949056 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin