Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4854013..4854615 Replicon chromosome
Accession NZ_CP104848
Organism Escherichia coli strain DFK.1

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag N7218_RS23815 Protein ID WP_000897302.1
Coordinates 4854304..4854615 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7218_RS23810 Protein ID WP_000356397.1
Coordinates 4854013..4854303 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7218_RS23780 (4849320) 4849320..4850249 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
N7218_RS23785 (4850431) 4850431..4850673 - 243 WP_001068514.1 CopG family transcriptional regulator -
N7218_RS23790 (4850963) 4850963..4851811 + 849 WP_001038650.1 hypothetical protein -
N7218_RS23795 (4851836) 4851836..4852576 + 741 WP_000608806.1 hypothetical protein -
N7218_RS23800 (4852761) 4852761..4852979 - 219 WP_001251293.1 CopG family transcriptional regulator -
N7218_RS23805 (4853376) 4853376..4853654 - 279 WP_001296612.1 hypothetical protein -
N7218_RS23810 (4854013) 4854013..4854303 - 291 WP_000356397.1 NadS family protein Antitoxin
N7218_RS23815 (4854304) 4854304..4854615 - 312 WP_000897302.1 hypothetical protein Toxin
N7218_RS23820 (4854844) 4854844..4855752 + 909 WP_001385591.1 alpha/beta hydrolase -
N7218_RS23825 (4855816) 4855816..4856757 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N7218_RS23830 (4856802) 4856802..4857239 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
N7218_RS23835 (4857236) 4857236..4858108 - 873 WP_000920762.1 virulence factor BrkB family protein -
N7218_RS23840 (4858102) 4858102..4858701 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T259312 WP_000897302.1 NZ_CP104848:c4854615-4854304 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT259312 WP_000356397.1 NZ_CP104848:c4854303-4854013 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References