Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3317407..3317909 Replicon chromosome
Accession NZ_CP104848
Organism Escherichia coli strain DFK.1

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag N7218_RS16765 Protein ID WP_000767819.1
Coordinates 3317407..3317661 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag N7218_RS16770 Protein ID WP_001259253.1
Coordinates 3317658..3317909 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7218_RS16740 (3313225) 3313225..3313683 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
N7218_RS16745 (3313900) 3313900..3315258 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
N7218_RS16750 (3315248) 3315248..3315310 - 63 WP_010723108.1 membrane protein YoeI -
N7218_RS16755 (3315525) 3315525..3316454 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
N7218_RS16760 (3316500) 3316500..3317324 - 825 WP_000754737.1 SDR family oxidoreductase -
N7218_RS16765 (3317407) 3317407..3317661 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N7218_RS16770 (3317658) 3317658..3317909 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N7218_RS16775 (3318192) 3318192..3318242 + 51 WP_001364200.1 his operon leader peptide -
N7218_RS16780 (3318388) 3318388..3319287 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
N7218_RS16785 (3319293) 3319293..3320597 + 1305 WP_001296211.1 histidinol dehydrogenase -
N7218_RS16790 (3320594) 3320594..3321664 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
N7218_RS16795 (3321664) 3321664..3322731 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3313225..3313683 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T259308 WP_000767819.1 NZ_CP104848:c3317661-3317407 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT259308 WP_001259253.1 NZ_CP104848:c3317909-3317658 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References