Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 600956..601755 Replicon chromosome
Accession NZ_CP104848
Organism Escherichia coli strain DFK.1

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag N7218_RS02955 Protein ID WP_000347251.1
Coordinates 600956..601420 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag N7218_RS02960 Protein ID WP_001296435.1
Coordinates 601420..601755 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7218_RS02925 (595957) 595957..596391 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
N7218_RS02930 (596409) 596409..597287 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
N7218_RS02935 (597277) 597277..598056 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N7218_RS02940 (598067) 598067..598540 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N7218_RS02945 (598563) 598563..599843 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
N7218_RS02950 (600092) 600092..600901 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N7218_RS02955 (600956) 600956..601420 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N7218_RS02960 (601420) 601420..601755 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N7218_RS02965 (601904) 601904..603475 - 1572 WP_001273763.1 galactarate dehydratase -
N7218_RS02970 (603850) 603850..605184 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
N7218_RS02975 (605200) 605200..605970 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T259288 WP_000347251.1 NZ_CP104848:c601420-600956 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT259288 WP_001296435.1 NZ_CP104848:c601755-601420 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References