Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4734686..4735288 Replicon chromosome
Accession NZ_CP104846
Organism Escherichia coli strain DFS.1

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag N7219_RS23170 Protein ID WP_000897302.1
Coordinates 4734977..4735288 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7219_RS23165 Protein ID WP_000356397.1
Coordinates 4734686..4734976 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7219_RS23135 (4729993) 4729993..4730922 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
N7219_RS23140 (4731104) 4731104..4731346 - 243 WP_001068514.1 CopG family transcriptional regulator -
N7219_RS23145 (4731636) 4731636..4732484 + 849 WP_001038650.1 hypothetical protein -
N7219_RS23150 (4732509) 4732509..4733249 + 741 WP_000608806.1 hypothetical protein -
N7219_RS23155 (4733434) 4733434..4733652 - 219 WP_001251293.1 CopG family transcriptional regulator -
N7219_RS23160 (4734049) 4734049..4734327 - 279 WP_001296612.1 hypothetical protein -
N7219_RS23165 (4734686) 4734686..4734976 - 291 WP_000356397.1 NadS family protein Antitoxin
N7219_RS23170 (4734977) 4734977..4735288 - 312 WP_000897302.1 hypothetical protein Toxin
N7219_RS23175 (4735517) 4735517..4736425 + 909 WP_001385591.1 alpha/beta hydrolase -
N7219_RS23180 (4736489) 4736489..4737430 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N7219_RS23185 (4737475) 4737475..4737912 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
N7219_RS23190 (4737909) 4737909..4738781 - 873 WP_000920762.1 virulence factor BrkB family protein -
N7219_RS23195 (4738775) 4738775..4739374 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T259277 WP_000897302.1 NZ_CP104846:c4735288-4734977 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT259277 WP_000356397.1 NZ_CP104846:c4734976-4734686 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References