Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3198080..3198582 Replicon chromosome
Accession NZ_CP104846
Organism Escherichia coli strain DFS.1

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag N7219_RS16125 Protein ID WP_000767819.1
Coordinates 3198080..3198334 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag N7219_RS16130 Protein ID WP_001259253.1
Coordinates 3198331..3198582 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7219_RS16100 (3193898) 3193898..3194356 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
N7219_RS16105 (3194573) 3194573..3195931 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
N7219_RS16110 (3195921) 3195921..3195983 - 63 WP_010723108.1 membrane protein YoeI -
N7219_RS16115 (3196198) 3196198..3197127 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
N7219_RS16120 (3197173) 3197173..3197997 - 825 WP_000754737.1 SDR family oxidoreductase -
N7219_RS16125 (3198080) 3198080..3198334 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N7219_RS16130 (3198331) 3198331..3198582 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N7219_RS16135 (3198865) 3198865..3198915 + 51 WP_001364200.1 his operon leader peptide -
N7219_RS16140 (3199061) 3199061..3199960 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
N7219_RS16145 (3199966) 3199966..3201270 + 1305 WP_001296211.1 histidinol dehydrogenase -
N7219_RS16150 (3201267) 3201267..3202337 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
N7219_RS16155 (3202337) 3202337..3203404 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3193898..3194356 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T259273 WP_000767819.1 NZ_CP104846:c3198334-3198080 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT259273 WP_001259253.1 NZ_CP104846:c3198582-3198331 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References