Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 661444..662243 Replicon chromosome
Accession NZ_CP104843
Organism Escherichia coli strain DFL.5

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag N7217_RS03140 Protein ID WP_000347273.1
Coordinates 661444..661908 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag N7217_RS03145 Protein ID WP_001308975.1
Coordinates 661908..662243 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7217_RS03110 (656445) 656445..656879 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
N7217_RS03115 (656897) 656897..657775 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
N7217_RS03120 (657765) 657765..658544 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N7217_RS03125 (658555) 658555..659028 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N7217_RS03130 (659051) 659051..660331 - 1281 WP_023908831.1 tagatose-bisphosphate aldolase subunit KbaZ -
N7217_RS03135 (660580) 660580..661389 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N7217_RS03140 (661444) 661444..661908 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N7217_RS03145 (661908) 661908..662243 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N7217_RS03150 (662392) 662392..663963 - 1572 WP_023908830.1 galactarate dehydratase -
N7217_RS03155 (664338) 664338..665672 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
N7217_RS03160 (665688) 665688..666458 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T259230 WP_000347273.1 NZ_CP104843:c661908-661444 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT259230 WP_001308975.1 NZ_CP104843:c662243-661908 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References