Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 355907..356547 Replicon chromosome
Accession NZ_CP104796
Organism Klebsiella pneumoniae strain GX34

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag N7T97_RS01990 Protein ID WP_016529833.1
Coordinates 355907..356254 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7T97_RS01995 Protein ID WP_040181955.1
Coordinates 356254..356547 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7T97_RS01980 (351833) 351833..353266 + 1434 WP_002920564.1 glycogen synthase GlgA -
N7T97_RS01985 (353284) 353284..355731 + 2448 WP_002920561.1 glycogen phosphorylase -
N7T97_RS01990 (355907) 355907..356254 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7T97_RS01995 (356254) 356254..356547 + 294 WP_040181955.1 helix-turn-helix transcriptional regulator Antitoxin
N7T97_RS02000 (356617) 356617..358125 - 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
N7T97_RS02005 (358330) 358330..358659 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
N7T97_RS02010 (358710) 358710..359540 + 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
N7T97_RS02015 (359590) 359590..360348 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T259190 WP_016529833.1 NZ_CP104796:355907-356254 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10539.30 Da        Isoelectric Point: 10.1464

>AT259190 WP_040181955.1 NZ_CP104796:356254-356547 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure

References