Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 305538..306079 Replicon chromosome
Accession NZ_CP104788
Organism Escherichia coli strain SHP24

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag N6H17_RS01415 Protein ID WP_000615983.1
Coordinates 305538..305816 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag N6H17_RS01420 Protein ID WP_000729703.1
Coordinates 305819..306079 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H17_RS01400 (303120) 303120..303698 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
N6H17_RS01405 (303904) 303904..304671 + 768 WP_000333380.1 class II glutamine amidotransferase -
N6H17_RS01410 (304642) 304642..305382 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
N6H17_RS01415 (305538) 305538..305816 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
N6H17_RS01420 (305819) 305819..306079 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
N6H17_RS01425 (306289) 306289..307038 + 750 WP_000056849.1 C40 family peptidase -
N6H17_RS01430 (307214) 307214..307711 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
N6H17_RS01435 (307935) 307935..309647 - 1713 Protein_279 flagellar biosynthesis protein FlhA -
N6H17_RS01440 (309619) 309619..310404 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T259157 WP_000615983.1 NZ_CP104788:c305816-305538 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT259157 WP_000729703.1 NZ_CP104788:c306079-305819 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References