Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2508170..2508859 Replicon chromosome
Accession NZ_CP104766
Organism Klebsiella pneumoniae strain IMT44613

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag N7Q99_RS12325 Protein ID WP_021469727.1
Coordinates 2508170..2508487 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag N7Q99_RS12330 Protein ID WP_020804705.1
Coordinates 2508563..2508859 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7Q99_RS12295 (2503872) 2503872..2504381 + 510 WP_020802144.1 GNAT family N-acetyltransferase -
N7Q99_RS12300 (2504391) 2504391..2505317 + 927 WP_032435210.1 amino acid ABC transporter permease -
N7Q99_RS12305 (2505301) 2505301..2506080 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
N7Q99_RS12310 (2506119) 2506119..2506970 + 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
N7Q99_RS12315 (2507048) 2507048..2507665 + 618 WP_032425015.1 glutathione S-transferase family protein -
N7Q99_RS12320 (2507736) 2507736..2507963 + 228 WP_002906690.1 tautomerase PptA -
N7Q99_RS12325 (2508170) 2508170..2508487 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7Q99_RS12330 (2508563) 2508563..2508859 + 297 WP_020804705.1 NadS family protein Antitoxin
N7Q99_RS12335 (2508938) 2508938..2509384 + 447 WP_032435212.1 hypothetical protein -
N7Q99_RS12340 (2509425) 2509425..2511041 - 1617 WP_004175961.1 carbohydrate porin -
N7Q99_RS12345 (2511085) 2511085..2512467 - 1383 WP_004151222.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T259145 WP_021469727.1 NZ_CP104766:2508170-2508487 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT259145 WP_020804705.1 NZ_CP104766:2508563-2508859 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References