Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4433013..4433677 Replicon chromosome
Accession NZ_CP104755
Organism Shewanella putrefaciens strain 4H

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N5094_RS19570 Protein ID WP_259650362.1
Coordinates 4433013..4433255 (+) Length 81 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5094_RS19575 Protein ID WP_014611555.1
Coordinates 4433261..4433677 (+) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5094_RS19550 (N5094_19550) 4428346..4431351 - 3006 WP_220778023.1 Tn3 family transposase -
N5094_RS19555 (N5094_19555) 4431514..4432077 + 564 WP_220778011.1 recombinase family protein -
N5094_RS19560 (N5094_19560) 4432233..4432496 + 264 Protein_3781 hypothetical protein -
N5094_RS19565 (N5094_19565) 4432552..4432647 - 96 Protein_3782 type II toxin-antitoxin system RelB/DinJ family antitoxin -
N5094_RS19570 (N5094_19570) 4433013..4433255 + 243 WP_259650362.1 type II toxin-antitoxin system HigB family toxin Toxin
N5094_RS19575 (N5094_19575) 4433261..4433677 + 417 WP_014611555.1 transcriptional regulator Antitoxin
N5094_RS19580 (N5094_19580) 4433886..4435094 - 1209 WP_001206290.1 IS4-like element IS10A family transposase -
N5094_RS19585 (N5094_19585) 4435408..4435662 + 255 WP_259524104.1 hypothetical protein -
N5094_RS19590 (N5094_19590) 4435727..4436866 + 1140 WP_019677804.1 AraC family transcriptional regulator -
N5094_RS19595 (N5094_19595) 4437083..4437673 + 591 WP_261762202.1 DUF6448 family protein -
N5094_RS19600 (N5094_19600) 4437782..4438057 - 276 WP_227510224.1 MipA/OmpV family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4428346..4435094 6748


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-70)

Antitoxin

(2-138)


Sequences


Toxin        


Download         Length: 81 a.a.        Molecular weight: 9645.93 Da        Isoelectric Point: 9.9876

>T259111 WP_259650362.1 NZ_CP104755:4433013-4433255 [Shewanella putrefaciens]
VQIYSTLRSGTFTNPDDLRQVFPSLDNFKYRDKWWVIDVGGNNLRIIAFIEFRDNRMYVKHVVSHADYSKLTDKYRRTKE

Download         Length: 243 bp


Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15520.72 Da        Isoelectric Point: 4.2543

>AT259111 WP_014611555.1 NZ_CP104755:4433261-4433677 [Shewanella putrefaciens]
MLPTACIEIREALAKVPYLAHIETQDDYEQALVLMDDLVDDYDSNKFLIEMLSLSIERWEEQADEFAEFNAAIAEMDSGI
AVLKTLMSQYRLGVADLPELGSKSNVSKLLNAAEGKKLNRHHIEALSQRFGVPVSLFF

Download         Length: 417 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References