Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 29590..30235 Replicon chromosome
Accession NZ_CP104733
Organism Pectobacterium sp. F1-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NAL19_RS00135 Protein ID WP_263059765.1
Coordinates 29876..30235 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NAL19_RS00130 Protein ID WP_180779427.1
Coordinates 29590..29889 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL19_RS00110 (NAL19_25) 24843..25832 + 990 WP_263058424.1 nucleoside hydrolase -
NAL19_RS00115 (NAL19_26) 25832..26809 + 978 WP_263058425.1 ABC transporter permease -
NAL19_RS00120 (NAL19_27) 26806..27714 + 909 WP_263058426.1 ABC transporter permease -
NAL19_RS00125 (NAL19_28) 27754..29553 + 1800 WP_263058427.1 ABC transporter ATP-binding protein -
NAL19_RS00130 (NAL19_29) 29590..29889 - 300 WP_180779427.1 XRE family transcriptional regulator Antitoxin
NAL19_RS00135 (NAL19_30) 29876..30235 - 360 WP_263059765.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NAL19_RS00140 (NAL19_31) 30478..30975 + 498 WP_225086386.1 GNAT family N-acetyltransferase -
NAL19_RS00145 (NAL19_32) 31175..31432 - 258 WP_263058428.1 DUF1471 domain-containing protein -
NAL19_RS00150 (NAL19_33) 31605..32405 - 801 WP_263058429.1 aliphatic sulfonates ABC transporter ATP-binding protein -
NAL19_RS00155 (NAL19_34) 32402..33196 - 795 WP_205549541.1 aliphatic sulfonate ABC transporter permease SsuC -
NAL19_RS00160 33207..34348 - 1142 Protein_31 FMNH2-dependent alkanesulfonate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 34629..35651 1022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(10-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13656.47 Da        Isoelectric Point: 4.8263

>T259080 WP_263059765.1 NZ_CP104733:c30235-29876 [Pectobacterium sp. F1-1]
IVTRALFDTWFDEQTETVQEEVLAHLGILEEDGPQLGRPQVDQIKGSQYKNMKELRVQVGGHPFRTFFAFDRTRKAIVLC
AGDKKGENEKLFYERMIKIADAEFTSHLISPEVKEDGDI

Download         Length: 360 bp

>T259080 NZ_CP104733:c30235-29876 [Pectobacterium sp. F1-1]
ATAGTCACACGGGCACTATTCGATACGTGGTTTGATGAGCAAACCGAAACGGTACAGGAAGAGGTTTTGGCACACCTCGG
TATACTCGAAGAAGATGGCCCACAGCTAGGGCGACCACAGGTTGATCAGATTAAAGGCTCACAATACAAAAATATGAAGG
AGCTTCGAGTTCAGGTTGGCGGCCACCCATTCCGAACATTCTTCGCATTTGATCGGACACGTAAAGCGATTGTTTTATGT
GCGGGAGATAAGAAAGGCGAAAATGAAAAATTGTTCTACGAACGTATGATTAAGATCGCAGACGCTGAGTTTACATCGCA
TCTGATATCACCGGAGGTAAAAGAAGATGGCGACATTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11082.10 Da        Isoelectric Point: 10.6442

>AT259080 WP_180779427.1 NZ_CP104733:c29889-29590 [Pectobacterium sp. F1-1]
MATFKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT259080 NZ_CP104733:c29889-29590 [Pectobacterium sp. F1-1]
ATGGCGACATTTAAAGAAATGATGGCTAAACGTTCACCGGAGAGCCGCGCCCGCATTGAAGCGCGCACGGCTGAGATCCG
TCAGGAAATCACTTTAGCGAAACTACGCGAAGAGCTGAACATGTCGCAGACTCAGCTTGCATTAGCTCTGGGCGTCAAGC
AGCCATCTATTGTTAAGATGGAGAAGGTCGAGAATGACCCAAAACTGTCAACGCTGAAACGCTATGTCACTGCCCTAGGC
GGCAAGCTTACGCTAGATGTGACCTTGCCTGATGGTAAGCGTATCGCGCTTACTTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References