Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1153174..1153823 Replicon chromosome
Accession NZ_CP104724
Organism Enterobacter kobei strain SG.H2a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N5P26_RS05405 Protein ID WP_196347061.1
Coordinates 1153461..1153823 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2W0GCS7
Locus tag N5P26_RS05400 Protein ID WP_014882863.1
Coordinates 1153174..1153473 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5P26_RS05390 (N5P26_05390) 1149599..1151572 + 1974 WP_063434035.1 PhoX family phosphatase -
N5P26_RS05395 (N5P26_05395) 1151675..1153063 + 1389 WP_196347059.1 phenylalanine transporter -
N5P26_RS05400 (N5P26_05400) 1153174..1153473 - 300 WP_014882863.1 helix-turn-helix transcriptional regulator Antitoxin
N5P26_RS05405 (N5P26_05405) 1153461..1153823 - 363 WP_196347061.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5P26_RS05410 (N5P26_05410) 1154029..1155264 + 1236 WP_023332295.1 MFS transporter -
N5P26_RS05415 (N5P26_05415) 1155280..1156305 + 1026 WP_063666829.1 sugar phosphate isomerase/epimerase family protein -
N5P26_RS05420 (N5P26_05420) 1156298..1157440 + 1143 WP_196347063.1 Gfo/Idh/MocA family oxidoreductase -
N5P26_RS05425 (N5P26_05425) 1157516..1158487 + 972 WP_196347065.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14053.04 Da        Isoelectric Point: 6.7121

>T259058 WP_196347061.1 NZ_CP104724:c1153823-1153461 [Enterobacter kobei]
MWNVETTDRFDQWYFEQTTALKEDVLAMMHILAEFGPTLGRPYVDTVKASAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCARDKTGCNQKRFYNEMITLADVEYSRHLADKEAIWQR

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10860.61 Da        Isoelectric Point: 9.8627

>AT259058 WP_014882863.1 NZ_CP104724:c1153473-1153174 [Enterobacter kobei]
MATLKELMAQQSAESQERIAAKVDVIRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2W0GCS7

References