Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 947956..948650 Replicon chromosome
Accession NZ_CP104724
Organism Enterobacter kobei strain SG.H2a

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag N5P26_RS04445 Protein ID WP_263441988.1
Coordinates 948246..948650 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID A0A285AZA0
Locus tag N5P26_RS04440 Protein ID WP_073395581.1
Coordinates 947956..948249 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5P26_RS04420 (N5P26_04420) 943872..944081 - 210 WP_133116564.1 hypothetical protein -
N5P26_RS04425 (N5P26_04425) 944122..945375 - 1254 WP_201505864.1 DUF3644 domain-containing protein -
N5P26_RS04430 (N5P26_04430) 945452..946432 - 981 WP_261660238.1 hypothetical protein -
N5P26_RS04435 (N5P26_04435) 946516..947415 - 900 WP_163330390.1 DUF4365 domain-containing protein -
N5P26_RS04440 (N5P26_04440) 947956..948249 + 294 WP_073395581.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
N5P26_RS04445 (N5P26_04445) 948246..948650 + 405 WP_263441988.1 type II toxin-antitoxin system YafO family toxin Toxin
N5P26_RS04450 (N5P26_04450) 949485..949865 - 381 WP_045281706.1 hypothetical protein -
N5P26_RS04455 (N5P26_04455) 950301..950768 - 468 WP_045281705.1 GNAT family N-acetyltransferase -
N5P26_RS04460 (N5P26_04460) 951065..951835 - 771 WP_213784176.1 class I SAM-dependent methyltransferase -
N5P26_RS04465 (N5P26_04465) 951846..952103 - 258 WP_014882706.1 YjhX family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 927303..950768 23465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(29-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15512.89 Da        Isoelectric Point: 7.1284

>T259056 WP_263441988.1 NZ_CP104724:948246-948650 [Enterobacter kobei]
MSIRIFKSALIRQQLIQQELDDLAADFLSYKKDGVLPDTFGRDAPYDDDRTYPLVKEEQVAHIHLADADAPFPKFLRQFK
RTSDQAHLVYCQGAMDPDAYLLIIILKPEAHKMARNNNHMHKIGMMAEAFRMKH

Download         Length: 405 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10979.44 Da        Isoelectric Point: 4.9167

>AT259056 WP_073395581.1 NZ_CP104724:947956-948249 [Enterobacter kobei]
MERILAEKSINITELRKNPAKYFIDEPVAVLSNNRPAGYMVSAKVFEELIDLLEEKQGRVHTGARFRPTAERLSDIADSG
QKLLQNASDKDLTEFTE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A285AZA0

References