Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5048608..5049203 Replicon chromosome
Accession NZ_CP104720
Organism Pseudomonas aeruginosa strain NY4593

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag N5P33_RS23515 Protein ID WP_003113526.1
Coordinates 5048925..5049203 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5P33_RS23510 Protein ID WP_003113527.1
Coordinates 5048608..5048913 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5P33_RS23475 (N5P33_23475) 5043748..5044596 + 849 WP_003146058.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
N5P33_RS23485 (N5P33_23485) 5044763..5045704 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
N5P33_RS23490 (N5P33_23490) 5045821..5046435 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
N5P33_RS23495 (N5P33_23495) 5046477..5047061 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
N5P33_RS23500 (N5P33_23500) 5047102..5048202 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
N5P33_RS23510 (N5P33_23510) 5048608..5048913 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
N5P33_RS23515 (N5P33_23515) 5048925..5049203 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5P33_RS23520 (N5P33_23520) 5049256..5049384 - 129 Protein_4642 integrase -
N5P33_RS23525 (N5P33_23525) 5049532..5051760 + 2229 WP_034071371.1 TonB-dependent receptor -
N5P33_RS23530 (N5P33_23530) 5051830..5052477 - 648 WP_003095021.1 carbonate dehydratase -
N5P33_RS23535 (N5P33_23535) 5052539..5053777 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T259034 WP_003113526.1 NZ_CP104720:c5049203-5048925 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT259034 WP_003113527.1 NZ_CP104720:c5048913-5048608 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References