Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4437264..4437945 Replicon chromosome
Accession NZ_CP104720
Organism Pseudomonas aeruginosa strain NY4593

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N5P33_RS20720 Protein ID WP_015503432.1
Coordinates 4437580..4437945 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A643IYQ7
Locus tag N5P33_RS20715 Protein ID WP_034071998.1
Coordinates 4437264..4437587 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5P33_RS20690 (N5P33_20690) 4433178..4433816 + 639 WP_034072001.1 hypothetical protein -
N5P33_RS20695 (N5P33_20695) 4434059..4434394 + 336 WP_003140884.1 TM2 domain-containing protein -
N5P33_RS20700 (N5P33_20700) 4434568..4435086 + 519 WP_022579807.1 PAAR domain-containing protein -
N5P33_RS20705 (N5P33_20705) 4435083..4435784 + 702 WP_003111822.1 VRR-NUC domain-containing protein -
N5P33_RS20710 (N5P33_20710) 4435801..4436889 + 1089 WP_034071999.1 DUF3396 domain-containing protein -
N5P33_RS20715 (N5P33_20715) 4437264..4437587 - 324 WP_034071998.1 XRE family transcriptional regulator Antitoxin
N5P33_RS20720 (N5P33_20720) 4437580..4437945 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5P33_RS20725 (N5P33_20725) 4438209..4438448 - 240 WP_044069615.1 hypothetical protein -
N5P33_RS20730 (N5P33_20730) 4438655..4438927 + 273 WP_003124230.1 hypothetical protein -
N5P33_RS20735 (N5P33_20735) 4438958..4439383 - 426 WP_003116492.1 VOC family protein -
N5P33_RS20740 (N5P33_20740) 4439484..4440368 + 885 WP_034071997.1 LysR substrate-binding domain-containing protein -
N5P33_RS20745 (N5P33_20745) 4440341..4441294 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
N5P33_RS20750 (N5P33_20750) 4441515..4441949 + 435 WP_134253793.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T259033 WP_015503432.1 NZ_CP104720:c4437945-4437580 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11926.76 Da        Isoelectric Point: 6.4751

>AT259033 WP_034071998.1 NZ_CP104720:c4437587-4437264 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GHLEVIARFPDGAVKISNFADIEETGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A643IYQ7

References