258981

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 767111..767804 Replicon chromosome
Accession NZ_CP104681
Organism Escherichia coli strain 2022CK-00450

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag N5922_RS03835 Protein ID WP_000415584.1
Coordinates 767111..767407 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag N5922_RS03840 Protein ID WP_000650107.1
Coordinates 767409..767804 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5922_RS03800 (762199) 762199..762513 - 315 WP_000958598.1 putative quinol monooxygenase -
N5922_RS03805 (762544) 762544..763125 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
N5922_RS03810 (763444) 763444..763776 + 333 WP_000917684.1 DUF2645 family protein -
N5922_RS03815 (763822) 763822..765171 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
N5922_RS03820 (765168) 765168..765827 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
N5922_RS03825 (765979) 765979..766371 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
N5922_RS03830 (766424) 766424..766906 + 483 WP_000183505.1 GyrI-like domain-containing protein -
N5922_RS03835 (767111) 767111..767407 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
N5922_RS03840 (767409) 767409..767804 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
N5922_RS03845 (767937) 767937..769544 + 1608 WP_222214717.1 ABC transporter substrate-binding protein -
N5922_RS03850 (769682) 769682..771940 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T258981 WP_000415584.1 NZ_CP104681:767111-767407 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT258981 WP_000650107.1 NZ_CP104681:767409-767804 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References