Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4560729..4561331 Replicon chromosome
Accession NZ_CP104677
Organism Salmonella enterica strain PNUSAS036471

Toxin (Protein)


Gene name higB Uniprot ID V7IUJ1
Locus tag N4534_RS22195 Protein ID WP_001159632.1
Coordinates 4561020..4561331 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4534_RS22190 Protein ID WP_000362050.1
Coordinates 4560729..4561019 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4534_RS22175 (4558222) 4558222..4559124 + 903 WP_000331365.1 formate dehydrogenase subunit beta -
N4534_RS22180 (4559121) 4559121..4559756 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
N4534_RS22185 (4559753) 4559753..4560682 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
N4534_RS22190 (4560729) 4560729..4561019 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
N4534_RS22195 (4561020) 4561020..4561331 - 312 WP_001159632.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
N4534_RS22200 (4561549) 4561549..4562478 + 930 WP_001127702.1 alpha/beta hydrolase -
N4534_RS22205 (4562564) 4562564..4562875 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
N4534_RS22210 (4562872) 4562872..4563318 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
N4534_RS22215 (4563333) 4563333..4564273 - 941 Protein_4337 fatty acid biosynthesis protein FabY -
N4534_RS22220 (4564318) 4564318..4564755 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
N4534_RS22225 (4564752) 4564752..4565624 - 873 WP_000921423.1 virulence factor BrkB family protein -
N4534_RS22230 (4565618) 4565618..4566217 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12342.27 Da        Isoelectric Point: 9.4460

>T258958 WP_001159632.1 NZ_CP104677:c4561331-4561020 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT258958 WP_000362050.1 NZ_CP104677:c4561019-4560729 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U7VQ31

Antitoxin

Source ID Structure

References