Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 29906..30618 Replicon plasmid unnamed2
Accession NZ_CP104667
Organism Escherichia coli strain 2021CK-00607

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N5914_RS25570 Protein ID WP_097452654.1
Coordinates 29906..30208 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5914_RS25575 Protein ID WP_000806445.1
Coordinates 30280..30618 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5914_RS25545 (N5914_25555) 25564..26469 - 906 WP_021551813.1 recombination-associated protein RdgC -
N5914_RS25550 (N5914_25560) 26529..27206 - 678 WP_016262377.1 hypothetical protein -
N5914_RS25555 (N5914_25565) 27203..28183 - 981 WP_094545091.1 tail length tape measure protein -
N5914_RS25560 (N5914_25570) 28187..28954 - 768 WP_094545090.1 baseplate -
N5914_RS25565 (N5914_25575) 28951..29742 - 792 WP_016262380.1 hypothetical protein -
N5914_RS25570 (N5914_25580) 29906..30208 + 303 WP_097452654.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5914_RS25575 (N5914_25585) 30280..30618 + 339 WP_000806445.1 HigA family addiction module antitoxin Antitoxin
N5914_RS25580 (N5914_25590) 30675..31034 + 360 WP_097452653.1 transcriptional regulator -
N5914_RS25585 (N5914_25595) 31096..31833 + 738 WP_261629118.1 hypothetical protein -
N5914_RS25590 (N5914_25600) 31867..33063 - 1197 WP_097765456.1 phage tail protein -
N5914_RS25595 (N5914_25605) 33056..33385 - 330 WP_016262385.1 hypothetical protein -
N5914_RS25600 (N5914_25610) 33717..34370 - 654 WP_021551806.1 hypothetical protein -
N5914_RS25605 (N5914_25615) 34495..35259 + 765 WP_236938445.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91750 91750


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11958.75 Da        Isoelectric Point: 10.0208

>T258941 WP_097452654.1 NZ_CP104667:29906-30208 [Escherichia coli]
MNKKINIKNFRDEWLDDFFEFSIPHKKIPSDIQITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNKQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13049.98 Da        Isoelectric Point: 6.4754

>AT258941 WP_000806445.1 NZ_CP104667:30280-30618 [Escherichia coli]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRINTAEKFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References