Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 4329519..4329931 Replicon chromosome
Accession NZ_CP104665
Organism Escherichia coli strain 2021CK-00607

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag N5914_RS20850 Protein ID WP_000132601.1
Coordinates 4329590..4329931 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 4329519..4329595 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5914_RS20840 (4326382) 4326382..4327971 + 1590 WP_001063200.1 type I restriction-modification system methyltransferase -
N5914_RS20845 (4327968) 4327968..4329362 + 1395 WP_001272445.1 type I restriction-modification system specificity subunit -
- (4329519) 4329519..4329595 - 77 NuclAT_7 - Antitoxin
- (4329519) 4329519..4329595 - 77 NuclAT_7 - Antitoxin
- (4329519) 4329519..4329595 - 77 NuclAT_7 - Antitoxin
- (4329519) 4329519..4329595 - 77 NuclAT_7 - Antitoxin
- (4329519) 4329519..4329595 - 77 NuclAT_8 - Antitoxin
- (4329519) 4329519..4329595 - 77 NuclAT_8 - Antitoxin
- (4329519) 4329519..4329595 - 77 NuclAT_8 - Antitoxin
- (4329519) 4329519..4329595 - 77 NuclAT_8 - Antitoxin
N5914_RS20850 (4329590) 4329590..4329931 + 342 WP_000132601.1 endoribonuclease SymE Toxin
N5914_RS20855 (4330093) 4330093..4331472 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
N5914_RS20860 (4331472) 4331472..4332518 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T258928 WP_000132601.1 NZ_CP104665:4329590-4329931 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT258928 NZ_CP104665:c4329595-4329519 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References