Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1425210..1425899 Replicon chromosome
Accession NZ_CP104659
Organism Klebsiella pneumoniae strain 2020CK-00096

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag N5936_RS06965 Protein ID WP_021469727.1
Coordinates 1425210..1425527 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag N5936_RS06970 Protein ID WP_020804705.1
Coordinates 1425603..1425899 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5936_RS06935 (1420912) 1420912..1421421 + 510 WP_020802144.1 GNAT family N-acetyltransferase -
N5936_RS06940 (1421431) 1421431..1422357 + 927 WP_032435210.1 amino acid ABC transporter permease -
N5936_RS06945 (1422341) 1422341..1423120 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
N5936_RS06950 (1423159) 1423159..1424010 + 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
N5936_RS06955 (1424088) 1424088..1424705 + 618 WP_032425015.1 glutathione S-transferase family protein -
N5936_RS06960 (1424776) 1424776..1425003 + 228 WP_002906690.1 tautomerase PptA -
N5936_RS06965 (1425210) 1425210..1425527 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5936_RS06970 (1425603) 1425603..1425899 + 297 WP_020804705.1 NadS family protein Antitoxin
N5936_RS06975 (1425978) 1425978..1426424 + 447 WP_032435212.1 hypothetical protein -
N5936_RS06980 (1426465) 1426465..1428081 - 1617 WP_004175961.1 carbohydrate porin -
N5936_RS06985 (1428125) 1428125..1429507 - 1383 WP_004151222.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T258885 WP_021469727.1 NZ_CP104659:1425210-1425527 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT258885 WP_020804705.1 NZ_CP104659:1425603-1425899 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References