258864

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 4216729..4217141 Replicon chromosome
Accession NZ_CP104649
Organism Escherichia coli strain PNUSAE008512

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag N5913_RS21495 Protein ID WP_000132630.1
Coordinates 4216729..4217070 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 4217065..4217141 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5913_RS21475 (4212740) 4212740..4214152 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
N5913_RS21480 (4214329) 4214329..4214493 + 165 WP_000394274.1 DUF1127 domain-containing protein -
N5913_RS21485 (4214590) 4214590..4215471 + 882 WP_001304007.1 DUF262 domain-containing protein -
N5913_RS21490 (4215519) 4215519..4216682 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
N5913_RS21495 (4216729) 4216729..4217070 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (4217065) 4217065..4217141 + 77 NuclAT_14 - Antitoxin
- (4217065) 4217065..4217141 + 77 NuclAT_14 - Antitoxin
- (4217065) 4217065..4217141 + 77 NuclAT_14 - Antitoxin
- (4217065) 4217065..4217141 + 77 NuclAT_14 - Antitoxin
- (4217065) 4217065..4217141 + 77 NuclAT_15 - Antitoxin
- (4217065) 4217065..4217141 + 77 NuclAT_15 - Antitoxin
- (4217065) 4217065..4217141 + 77 NuclAT_15 - Antitoxin
- (4217065) 4217065..4217141 + 77 NuclAT_15 - Antitoxin
N5913_RS21500 (4217291) 4217291..4219045 - 1755 WP_000110082.1 restriction endonuclease subunit S -
N5913_RS21505 (4219045) 4219045..4220514 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4206222..4224942 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T258864 WP_000132630.1 NZ_CP104649:c4217070-4216729 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT258864 NZ_CP104649:4217065-4217141 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References