Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2782455..2783182 Replicon chromosome
Accession NZ_CP104649
Organism Escherichia coli strain PNUSAE008512

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag N5913_RS14650 Protein ID WP_000550189.1
Coordinates 2782868..2783182 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5913_RS14645 Protein ID WP_000560249.1
Coordinates 2782455..2782871 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5913_RS14635 (2777515) 2777515..2779866 + 2352 WP_000695517.1 alpha-glucosidase -
N5913_RS14640 (2780392) 2780392..2782410 + 2019 WP_000121479.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
N5913_RS14645 (2782455) 2782455..2782871 - 417 WP_000560249.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
N5913_RS14650 (2782868) 2782868..2783182 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
N5913_RS14655 (2783466) 2783466..2784602 - 1137 WP_000018678.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
N5913_RS14660 (2784687) 2784687..2785190 + 504 WP_001295542.1 M48 family metallopeptidase -
N5913_RS14665 (2785267) 2785267..2785959 + 693 WP_000942543.1 vancomycin high temperature exclusion protein -
N5913_RS14670 (2786038) 2786038..2787024 + 987 WP_000617675.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Antitoxin HigA

(1-138)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T258855 WP_000550189.1 NZ_CP104649:c2783182-2782868 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15016.48 Da        Isoelectric Point: 4.5805

>AT258855 WP_000560249.1 NZ_CP104649:c2782871-2782455 [Escherichia coli]
MIAIADILHAGEKLTAVAPFLAGIQNEEQYIQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References