Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 900230..900701 Replicon chromosome
Accession NZ_CP104649
Organism Escherichia coli strain PNUSAE008512

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag N5913_RS04900 Protein ID WP_001303511.1
Coordinates 900423..900701 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag N5913_RS04895 Protein ID WP_001302048.1
Coordinates 900230..900421 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5913_RS04855 (895437) 895437..896021 - 585 WP_000206793.1 DUF551 domain-containing protein -
N5913_RS04860 (896078) 896078..896473 - 396 WP_001118159.1 DUF977 family protein -
N5913_RS04865 (896489) 896489..897258 - 770 Protein_958 DUF1627 domain-containing protein -
N5913_RS04870 (897284) 897284..898024 - 741 WP_000788938.1 ATP-binding protein -
N5913_RS04875 (898031) 898031..898993 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
N5913_RS04880 (899016) 899016..899441 - 426 WP_000693943.1 toxin YdaT family protein -
N5913_RS04885 (899438) 899438..899740 - 303 WP_000172738.1 transcriptional regulator -
N5913_RS04890 (899838) 899838..900209 + 372 WP_001169686.1 hypothetical protein -
N5913_RS04895 (900230) 900230..900421 + 192 WP_001302048.1 hypothetical protein Antitoxin
N5913_RS04900 (900423) 900423..900701 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5913_RS04905 (901054) 901054..901353 + 300 WP_001240334.1 hypothetical protein -
N5913_RS04910 (901425) 901425..901643 + 219 WP_001171930.1 protein YdfC -
N5913_RS04915 (902212) 902212..902400 + 189 WP_000449192.1 cell division inhibition protein DicB -
N5913_RS04920 (902397) 902397..902588 + 192 WP_001090200.1 DUF1482 family protein -
N5913_RS04925 (902681) 902681..903766 + 1086 Protein_970 exonuclease -
N5913_RS04930 (903817) 903817..905030 + 1214 WP_220572504.1 IS3-like element IS1203 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 817838..909175 91337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T258847 WP_001303511.1 NZ_CP104649:900423-900701 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT258847 WP_001302048.1 NZ_CP104649:900230-900421 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References