Detailed information of TA system TA258832

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4128001..4128226
• Replicon: chromosome
• Accession: NZ_CP104647
• Organism: Escherichia coli strain PNUSAE008406

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: N5921_RS20160
• Protein ID: WP_000813263.1
• Coordinates: 4128071..4128226 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4128001..4128059 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N5921_RS20130	4123270..4124367	+	1098	WP_001475117.1	hypothetical protein	-
N5921_RS20135	4124374..4125120	+	747	WP_000788745.1	ATP-binding protein	-
N5921_RS20140	4125142..4125912	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
N5921_RS20145	4125928..4126341	+	414	WP_001151233.1	DUF977 family protein	-
N5921_RS20150	4126693..4127466	-	774	WP_000160654.1	alpha/beta hydrolase	-
N5921_RS20155	4127728..4127811	+	84	Protein_3919	ORF6N domain-containing protein	-
-	4128001..4128059	-	59	-	-	Antitoxin
N5921_RS20160	4128071..4128226	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
N5921_RS20165	4128394..4128672	+	279	WP_001341388.1	hypothetical protein	-
N5921_RS20170	4128674..4129723	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
N5921_RS20175	4129736..4130107	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
N5921_RS20180	4130097..4130468	+	372	WP_000090264.1	antiterminator Q family protein	-
N5921_RS20185	4130620..4131438	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
N5921_RS20190	4131725..4131921	+	197	Protein_3926	TrmB family transcriptional regulator	-
N5921_RS20195	4132059..4132772	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T258832 WP_000813263.1 NZ_CP104647:4128071-4128226 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT258832 NZ_CP104647:c4128059-4128001 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin