Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3240899..3241593 Replicon chromosome
Accession NZ_CP104647
Organism Escherichia coli strain PNUSAE008406

Toxin (Protein)


Gene name yafO Uniprot ID C3TNX7
Locus tag N5921_RS15995 Protein ID WP_001263495.1
Coordinates 3241195..3241593 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag N5921_RS15990 Protein ID WP_000554757.1
Coordinates 3240899..3241192 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5921_RS15970 (3236610) 3236610..3237107 + 498 Protein_3099 REP-associated tyrosine transposase RayT -
N5921_RS15975 (3237252) 3237252..3238964 - 1713 Protein_3100 flagellar biosynthesis protein FlhA -
N5921_RS15980 (3238936) 3238936..3239721 + 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
N5921_RS15985 (3239792) 3239792..3240847 + 1056 WP_001226186.1 DNA polymerase IV -
N5921_RS15990 (3240899) 3240899..3241192 + 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
N5921_RS15995 (3241195) 3241195..3241593 + 399 WP_001263495.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
N5921_RS16000 (3241603) 3241603..3242055 + 453 WP_001059871.1 GNAT family N-acetyltransferase -
N5921_RS16005 (3242374) 3242374..3242577 + 204 Protein_3106 RtcB family protein -
N5921_RS16010 (3242576) 3242576..3243097 + 522 Protein_3107 peptide chain release factor H -
N5921_RS16015 (3243154) 3243154..3244611 - 1458 WP_001293009.1 cytosol nonspecific dipeptidase -
N5921_RS16020 (3244872) 3244872..3245330 + 459 WP_001291990.1 xanthine phosphoribosyltransferase -
- (3245926) 3245926..3246006 + 81 NuclAT_11 - -
- (3245926) 3245926..3246006 + 81 NuclAT_11 - -
- (3245926) 3245926..3246006 + 81 NuclAT_11 - -
- (3245926) 3245926..3246006 + 81 NuclAT_11 - -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15473.86 Da        Isoelectric Point: 8.0949

>T258828 WP_001263495.1 NZ_CP104647:3241195-3241593 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDESHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT258828 WP_000554757.1 NZ_CP104647:3240899-3241192 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References