Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 2887313..2887725 Replicon chromosome
Accession NZ_CP104647
Organism Escherichia coli strain PNUSAE008406

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag N5921_RS14375 Protein ID WP_000132630.1
Coordinates 2887313..2887654 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 2887649..2887725 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5921_RS14355 (2883324) 2883324..2884736 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
N5921_RS14360 (2884913) 2884913..2885077 + 165 WP_000394274.1 DUF1127 domain-containing protein -
N5921_RS14365 (2885174) 2885174..2886055 + 882 WP_001304007.1 DUF262 domain-containing protein -
N5921_RS14370 (2886103) 2886103..2887266 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
N5921_RS14375 (2887313) 2887313..2887654 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (2887649) 2887649..2887725 + 77 NuclAT_14 - Antitoxin
- (2887649) 2887649..2887725 + 77 NuclAT_14 - Antitoxin
- (2887649) 2887649..2887725 + 77 NuclAT_14 - Antitoxin
- (2887649) 2887649..2887725 + 77 NuclAT_14 - Antitoxin
- (2887649) 2887649..2887725 + 77 NuclAT_15 - Antitoxin
- (2887649) 2887649..2887725 + 77 NuclAT_15 - Antitoxin
- (2887649) 2887649..2887725 + 77 NuclAT_15 - Antitoxin
- (2887649) 2887649..2887725 + 77 NuclAT_15 - Antitoxin
N5921_RS14380 (2887875) 2887875..2889629 - 1755 WP_000110082.1 restriction endonuclease subunit S -
N5921_RS14385 (2889629) 2889629..2891098 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2876806..2895526 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T258823 WP_000132630.1 NZ_CP104647:c2887654-2887313 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT258823 NZ_CP104647:2887649-2887725 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References