258783

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1481138..1481937 Replicon chromosome
Accession NZ_CP104645
Organism Escherichia coli strain PNUSAE019785

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag N5932_RS07650 Protein ID WP_000347273.1
Coordinates 1481473..1481937 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID C3ST72
Locus tag N5932_RS07645 Protein ID WP_001302819.1
Coordinates 1481138..1481473 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5932_RS07630 (1476923) 1476923..1477693 - 771 WP_001058231.1 2-dehydro-3-deoxyglucarate aldolase -
N5932_RS07635 (1477709) 1477709..1479043 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
N5932_RS07640 (1479418) 1479418..1480989 + 1572 WP_001273776.1 galactarate dehydratase -
N5932_RS07645 (1481138) 1481138..1481473 + 336 WP_001302819.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N5932_RS07650 (1481473) 1481473..1481937 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N5932_RS07655 (1481992) 1481992..1482801 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N5932_RS07660 (1483050) 1483050..1484330 + 1281 WP_000681927.1 tagatose-bisphosphate aldolase subunit KbaZ -
N5932_RS07665 (1484353) 1484353..1484826 + 474 WP_001301475.1 PTS N-acetylgalactosamine transporter subunit IIB -
N5932_RS07670 (1484837) 1484837..1485616 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N5932_RS07675 (1485606) 1485606..1486484 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
N5932_RS07680 (1486502) 1486502..1486936 + 435 WP_000948831.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T258783 WP_000347273.1 NZ_CP104645:1481473-1481937 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12388.97 Da        Isoelectric Point: 4.8616

>AT258783 WP_001302819.1 NZ_CP104645:1481138-1481473 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDTDIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure

References