258759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 160623..161225 Replicon chromosome
Accession NZ_CP104643
Organism Salmonella enterica strain 1020677

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag N5930_RS00750 Protein ID WP_001159635.1
Coordinates 160914..161225 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5930_RS00745 Protein ID WP_000362050.1
Coordinates 160623..160913 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5930_RS00730 (158116) 158116..159018 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
N5930_RS00735 (159015) 159015..159650 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
N5930_RS00740 (159647) 159647..160576 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
N5930_RS00745 (160623) 160623..160913 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
N5930_RS00750 (160914) 160914..161225 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
N5930_RS00755 (161443) 161443..162372 + 930 WP_001127705.1 alpha/beta hydrolase -
N5930_RS00760 (162458) 162458..162769 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
N5930_RS00765 (162766) 162766..163212 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
N5930_RS00770 (163227) 163227..164168 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
N5930_RS00775 (164213) 164213..164650 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
N5930_RS00780 (164647) 164647..165519 - 873 WP_000921423.1 virulence factor BrkB family protein -
N5930_RS00785 (165513) 165513..166112 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T258759 WP_001159635.1 NZ_CP104643:c161225-160914 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT258759 WP_000362050.1 NZ_CP104643:c160913-160623 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References