Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4527698..4528300 Replicon chromosome
Accession NZ_CP104641
Organism Salmonella enterica strain 1019942

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag N5927_RS22075 Protein ID WP_001159635.1
Coordinates 4527989..4528300 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5927_RS22070 Protein ID WP_000362050.1
Coordinates 4527698..4527988 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5927_RS22055 (4525191) 4525191..4526093 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
N5927_RS22060 (4526090) 4526090..4526725 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
N5927_RS22065 (4526722) 4526722..4527651 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
N5927_RS22070 (4527698) 4527698..4527988 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
N5927_RS22075 (4527989) 4527989..4528300 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
N5927_RS22080 (4528518) 4528518..4529447 + 930 WP_001127705.1 alpha/beta hydrolase -
N5927_RS22085 (4529533) 4529533..4529844 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
N5927_RS22090 (4529841) 4529841..4530287 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
N5927_RS22095 (4530302) 4530302..4531243 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
N5927_RS22100 (4531288) 4531288..4531725 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
N5927_RS22105 (4531722) 4531722..4532594 - 873 WP_000921423.1 virulence factor BrkB family protein -
N5927_RS22110 (4532588) 4532588..4533187 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T258756 WP_001159635.1 NZ_CP104641:c4528300-4527989 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT258756 WP_000362050.1 NZ_CP104641:c4527988-4527698 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References