Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1304849..1305576 Replicon chromosome
Accession NZ_CP104639
Organism Escherichia coli strain PNUSAE014970

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag N4555_RS06405 Protein ID WP_000550189.1
Coordinates 1305262..1305576 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4555_RS06400 Protein ID WP_000560249.1
Coordinates 1304849..1305265 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4555_RS06390 (1299909) 1299909..1302260 + 2352 WP_000695517.1 alpha-glucosidase -
N4555_RS06395 (1302786) 1302786..1304804 + 2019 WP_000121479.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
N4555_RS06400 (1304849) 1304849..1305265 - 417 WP_000560249.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
N4555_RS06405 (1305262) 1305262..1305576 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
N4555_RS06410 (1305860) 1305860..1306996 - 1137 WP_000018678.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
N4555_RS06415 (1307081) 1307081..1307584 + 504 WP_001295542.1 M48 family metallopeptidase -
N4555_RS06420 (1307661) 1307661..1308353 + 693 WP_000942543.1 vancomycin high temperature exclusion protein -
N4555_RS06425 (1308432) 1308432..1309418 + 987 WP_000617675.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Antitoxin HigA

(1-138)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T258712 WP_000550189.1 NZ_CP104639:c1305576-1305262 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15016.48 Da        Isoelectric Point: 4.5805

>AT258712 WP_000560249.1 NZ_CP104639:c1305265-1304849 [Escherichia coli]
MIAIADILHAGEKLTAVAPFLAGIQNEEQYIQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References