Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 66811..67468 Replicon plasmid unnamed1
Accession NZ_CP104637
Organism Salmonella enterica strain PNUSAS118466

Toxin (Protein)


Gene name higB Uniprot ID U3PDC3
Locus tag N4311_RS00380 Protein ID WP_000270043.1
Coordinates 66811..67161 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4311_RS00385 Protein ID WP_000124640.1
Coordinates 67166..67468 (+) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4311_RS00335 (N4311_00335) 62122..62301 + 180 Protein_66 helix-turn-helix domain-containing protein -
N4311_RS00340 (N4311_00340) 62366..63070 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
N4311_RS00345 (N4311_00345) 63285..63782 - 498 WP_000062185.1 hypothetical protein -
N4311_RS00350 (N4311_00350) 63785..64273 - 489 WP_001273096.1 DUF1643 domain-containing protein -
N4311_RS00355 (N4311_00355) 64370..64705 + 336 WP_000683476.1 hypothetical protein -
N4311_RS00360 (N4311_00360) 64720..65190 - 471 WP_001281821.1 hypothetical protein -
N4311_RS00365 (N4311_00365) 65183..65554 - 372 WP_000516916.1 hypothetical protein -
N4311_RS00370 (N4311_00370) 65565..65759 - 195 WP_000343597.1 hypothetical protein -
N4311_RS00375 (N4311_00375) 66100..66648 - 549 WP_001061574.1 transcriptional regulator -
N4311_RS00380 (N4311_00380) 66811..67161 + 351 WP_000270043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4311_RS00385 (N4311_00385) 67166..67468 + 303 WP_000124640.1 XRE family transcriptional regulator Antitoxin
N4311_RS00390 (N4311_00390) 67495..67788 - 294 WP_001239997.1 chromosome segregation protein ParM -
N4311_RS00395 (N4311_00395) 67876..68148 - 273 WP_001043047.1 HU family DNA-binding protein -
N4311_RS00400 (N4311_00400) 68206..68733 - 528 WP_001236377.1 thermonuclease family protein -
N4311_RS00405 (N4311_00405) 68964..69821 - 858 WP_001167032.1 hypothetical protein -
N4311_RS00410 (N4311_00410) 69808..70038 - 231 WP_000972663.1 hypothetical protein -
N4311_RS00415 (N4311_00415) 70038..70556 - 519 WP_000210756.1 nitrite reductase -
N4311_RS00420 (N4311_00420) 70553..70999 - 447 WP_000919345.1 Fe3+-siderophore ABC transporter permease -
N4311_RS00425 (N4311_00425) 70999..71358 - 360 WP_000422768.1 hypothetical protein -
N4311_RS00430 (N4311_00430) 71415..71843 - 429 WP_000591074.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCMY-2 / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR - 1..158207 158207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-106)

Antitoxin

(33-79)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 13328.21 Da        Isoelectric Point: 5.2421

>T258694 WP_000270043.1 NZ_CP104637:66811-67161 [Salmonella enterica]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE

Download         Length: 351 bp


Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11006.73 Da        Isoelectric Point: 7.2036

>AT258694 WP_000124640.1 NZ_CP104637:67166-67468 [Salmonella enterica]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV

Download         Length: 303 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7G8AFB9


Antitoxin

Source ID Structure

References