Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 66811..67468 | Replicon | plasmid unnamed1 |
Accession | NZ_CP104637 | ||
Organism | Salmonella enterica strain PNUSAS118466 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U3PDC3 |
Locus tag | N4311_RS00380 | Protein ID | WP_000270043.1 |
Coordinates | 66811..67161 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | N4311_RS00385 | Protein ID | WP_000124640.1 |
Coordinates | 67166..67468 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N4311_RS00335 (N4311_00335) | 62122..62301 | + | 180 | Protein_66 | helix-turn-helix domain-containing protein | - |
N4311_RS00340 (N4311_00340) | 62366..63070 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
N4311_RS00345 (N4311_00345) | 63285..63782 | - | 498 | WP_000062185.1 | hypothetical protein | - |
N4311_RS00350 (N4311_00350) | 63785..64273 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
N4311_RS00355 (N4311_00355) | 64370..64705 | + | 336 | WP_000683476.1 | hypothetical protein | - |
N4311_RS00360 (N4311_00360) | 64720..65190 | - | 471 | WP_001281821.1 | hypothetical protein | - |
N4311_RS00365 (N4311_00365) | 65183..65554 | - | 372 | WP_000516916.1 | hypothetical protein | - |
N4311_RS00370 (N4311_00370) | 65565..65759 | - | 195 | WP_000343597.1 | hypothetical protein | - |
N4311_RS00375 (N4311_00375) | 66100..66648 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
N4311_RS00380 (N4311_00380) | 66811..67161 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
N4311_RS00385 (N4311_00385) | 67166..67468 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
N4311_RS00390 (N4311_00390) | 67495..67788 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
N4311_RS00395 (N4311_00395) | 67876..68148 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
N4311_RS00400 (N4311_00400) | 68206..68733 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
N4311_RS00405 (N4311_00405) | 68964..69821 | - | 858 | WP_001167032.1 | hypothetical protein | - |
N4311_RS00410 (N4311_00410) | 69808..70038 | - | 231 | WP_000972663.1 | hypothetical protein | - |
N4311_RS00415 (N4311_00415) | 70038..70556 | - | 519 | WP_000210756.1 | nitrite reductase | - |
N4311_RS00420 (N4311_00420) | 70553..70999 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
N4311_RS00425 (N4311_00425) | 70999..71358 | - | 360 | WP_000422768.1 | hypothetical protein | - |
N4311_RS00430 (N4311_00430) | 71415..71843 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaCMY-2 / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR | - | 1..158207 | 158207 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T258694 WP_000270043.1 NZ_CP104637:66811-67161 [Salmonella enterica]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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