Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3188845..3189644 Replicon chromosome
Accession NZ_CP104629
Organism Escherichia coli strain AHM21C2872I

Toxin (Protein)


Gene name yhaV Uniprot ID A0A161R7C1
Locus tag N5855_RS15285 Protein ID WP_000347278.1
Coordinates 3189180..3189644 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N5855_RS15280 Protein ID WP_001307405.1
Coordinates 3188845..3189180 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5855_RS15265 (3184630) 3184630..3185400 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
N5855_RS15270 (3185416) 3185416..3186750 - 1335 WP_000599633.1 galactarate/glucarate/glycerate transporter GarP -
N5855_RS15275 (3187125) 3187125..3188696 + 1572 WP_001273763.1 galactarate dehydratase -
N5855_RS15280 (3188845) 3188845..3189180 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N5855_RS15285 (3189180) 3189180..3189644 + 465 WP_000347278.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N5855_RS15290 (3189699) 3189699..3190508 - 810 WP_000072174.1 aga operon transcriptional regulator AgaR -
N5855_RS15295 (3190757) 3190757..3192037 + 1281 WP_021557243.1 tagatose-bisphosphate aldolase subunit KbaZ -
N5855_RS15300 (3192060) 3192060..3192533 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N5855_RS15305 (3192544) 3192544..3193323 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N5855_RS15310 (3193313) 3193313..3194191 + 879 WP_021557244.1 PTS N-acetylgalactosamine transporter subunit IID -
N5855_RS15315 (3194209) 3194209..3194643 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3180083..3189644 9561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17866.28 Da        Isoelectric Point: 9.6924

>T258682 WP_000347278.1 NZ_CP104629:3189180-3189644 [Escherichia coli]
MDFPQRVNGWALYTHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT258682 WP_001307405.1 NZ_CP104629:3188845-3189180 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A161R7C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References