Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 723481..724256 Replicon chromosome
Accession NZ_CP104627
Organism Klebsiella pneumoniae strain AHM21C2836KI

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag N5857_RS03605 Protein ID WP_009308645.1
Coordinates 723771..724256 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag N5857_RS03600 Protein ID WP_004150912.1
Coordinates 723481..723774 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5857_RS03580 (718689) 718689..719291 - 603 WP_004174410.1 short chain dehydrogenase -
N5857_RS03585 (719389) 719389..720300 + 912 WP_023342207.1 LysR family transcriptional regulator -
N5857_RS03590 (720301) 720301..721449 - 1149 WP_200541384.1 PLP-dependent aspartate aminotransferase family protein -
N5857_RS03595 (721460) 721460..722836 - 1377 WP_167877958.1 pyridoxal-phosphate dependent enzyme -
N5857_RS03600 (723481) 723481..723774 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
N5857_RS03605 (723771) 723771..724256 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
N5857_RS03610 (724960) 724960..725553 + 594 WP_200541383.1 hypothetical protein -
N5857_RS03615 (725650) 725650..725866 + 217 Protein_709 transposase -
N5857_RS03625 (726707) 726707..727420 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 725650..725802 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T258657 WP_009308645.1 NZ_CP104627:723771-724256 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT258657 WP_004150912.1 NZ_CP104627:723481-723774 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References