Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 82986..83239 Replicon plasmid pHNAH968-2
Accession NZ_CP104621
Organism Escherichia coli strain AHM9C68I

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag N5859_RS24415 Protein ID WP_001312851.1
Coordinates 83090..83239 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 82986..83045 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5859_RS24390 (79713) 79713..80459 + 747 WP_000205770.1 conjugal transfer pilus acetylase TraX -
N5859_RS24395 (80514) 80514..81074 + 561 WP_063097573.1 fertility inhibition protein FinO -
N5859_RS24400 (81206) 81206..81406 + 201 WP_015059022.1 hypothetical protein -
N5859_RS24405 (81792) 81792..82391 + 600 WP_032083981.1 PIN domain-containing protein -
N5859_RS24410 (82453) 82453..82785 + 333 WP_152916585.1 hypothetical protein -
- (82986) 82986..83045 - 60 NuclAT_1 - Antitoxin
- (82986) 82986..83045 - 60 NuclAT_1 - Antitoxin
- (82986) 82986..83045 - 60 NuclAT_1 - Antitoxin
- (82986) 82986..83045 - 60 NuclAT_1 - Antitoxin
N5859_RS24415 (83090) 83090..83239 + 150 WP_001312851.1 Hok/Gef family protein Toxin
N5859_RS24420 (83523) 83523..83771 + 249 WP_000083837.1 replication regulatory protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-55 / blaTEM-1B / rmtB - 1..84082 84082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T258651 WP_001312851.1 NZ_CP104621:83090-83239 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

Antitoxin


Download         Length: 60 bp

>AT258651 NZ_CP104621:c83045-82986 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References