Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1780026..1780528 Replicon chromosome
Accession NZ_CP104618
Organism Escherichia coli strain AHM9C68I

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8E0FJZ4
Locus tag N5859_RS08505 Protein ID WP_000767833.1
Coordinates 1780274..1780528 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N5859_RS08500 Protein ID WP_001259255.1
Coordinates 1780026..1780277 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5859_RS08475 (1775205) 1775205..1776272 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N5859_RS08480 (1776272) 1776272..1777342 - 1071 WP_000108969.1 histidinol-phosphate transaminase -
N5859_RS08485 (1777339) 1777339..1778643 - 1305 WP_053271967.1 histidinol dehydrogenase -
N5859_RS08490 (1778649) 1778649..1779548 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
N5859_RS08495 (1779694) 1779694..1779744 - 51 WP_152929649.1 his operon leader peptide -
N5859_RS08500 (1780026) 1780026..1780277 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N5859_RS08505 (1780274) 1780274..1780528 + 255 WP_000767833.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N5859_RS08510 (1780611) 1780611..1781435 + 825 WP_032202495.1 SDR family oxidoreductase -
N5859_RS08515 (1781481) 1781481..1782410 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N5859_RS08520 (1782625) 1782625..1782687 + 63 WP_010723108.1 membrane protein YoeI -
N5859_RS08525 (1782677) 1782677..1784035 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N5859_RS08530 (1784214) 1784214..1785116 + 903 Protein_1665 YeeE/YedE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10173.54 Da        Isoelectric Point: 8.0353

>T258630 WP_000767833.1 NZ_CP104618:1780274-1780528 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPESLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT258630 WP_001259255.1 NZ_CP104618:1780026-1780277 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References