Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 153703..154430 | Replicon | plasmid pHNAH8161B-2 |
| Accession | NZ_CP104605 | ||
| Organism | Klebsiella pneumoniae strain AHM8C161BI | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | N5862_RS28580 | Protein ID | WP_011251285.1 |
| Coordinates | 154119..154430 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | N5862_RS28575 | Protein ID | WP_011251286.1 |
| Coordinates | 153703..154122 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N5862_RS28550 (N5862_28540) | 149295..150662 | + | 1368 | WP_017900870.1 | formimidoylglutamate deiminase | - |
| N5862_RS28555 (N5862_28545) | 151187..151722 | + | 536 | Protein_168 | transposase | - |
| N5862_RS28560 (N5862_28550) | 151836..152102 | - | 267 | WP_017900868.1 | hypothetical protein | - |
| N5862_RS28565 (N5862_28555) | 152206..153174 | + | 969 | Protein_170 | IS5 family transposase | - |
| N5862_RS28570 (N5862_28560) | 153220..153633 | - | 414 | WP_017901337.1 | hypothetical protein | - |
| N5862_RS28575 (N5862_28565) | 153703..154122 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| N5862_RS28580 (N5862_28570) | 154119..154430 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| N5862_RS28585 (N5862_28575) | 154635..155072 | - | 438 | Protein_174 | DDE-type integrase/transposase/recombinase | - |
| N5862_RS28590 (N5862_28580) | 155186..155563 | + | 378 | WP_004118218.1 | transposase | - |
| N5862_RS28595 (N5862_28585) | 155560..155907 | + | 348 | WP_032430752.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| N5862_RS28600 (N5862_28590) | 155956..157494 | + | 1539 | WP_017901237.1 | IS66 family transposase | - |
| N5862_RS28605 (N5862_28595) | 157534..157713 | + | 180 | Protein_178 | IS5/IS1182 family transposase | - |
| N5862_RS28610 (N5862_28600) | 158259..159239 | - | 981 | WP_012569499.1 | IS5-like element ISKpn26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | qnrB4 / blaDHA-1 / sul1 / blaTEM-1B / mph(A) / qacE / aadA2 / dfrA12 | - | 1..218818 | 218818 | |
| - | inside | IScluster/Tn | blaTEM-1B | - | 151504..164103 | 12599 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T258591 WP_011251285.1 NZ_CP104605:c154430-154119 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT258591 WP_011251286.1 NZ_CP104605:c154122-153703 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|